Chronic granulomatous disease
A rare genetic disorder with a predominantly X-linked recessive pattern of inheritance resulting in impaired phagocytic clearance of bacteria and fungi. It is caused by a defect in the phagocytic NADPH oxidase (phox) complex. The phagocytes can engulf pathogens but are unable to produce the microbicidal precursors needed to destroy them. Clinical signs of severe disease present in childhood with milder forms later in life. They include recurrent infection especially pneumonia, cervical lymphadenopathy and hepatosplenomegaly. The clinical course includes the appearance of granulomata in the skin and gastrointestinal or genitourinary tracts. The clinical prognosis is dependent on effectively treating and preventing infection.
Disease Alternative Name
Rhinoscleroma - Chronic Granulomatous disease
25 Views
, 3 Answers
Recent Cases of Chronic granulomatous disease
Browse recently discussed Chronic granulomatous disease cases by specialistsTop Cases of Chronic granulomatous disease
Selected by editors, top cases are known for unique problem or best solutionTop Chronic granulomatous disease Doctors on Curofy
Top doctors who continously share their opinions on Chronic granulomatous diseaseSuper Specialist in Reproductive Endocrinology
.
.
PGIMER, Chandigarh
MD
Self Emploid(private Clinic)
Morbi
Shri M P Shah Medical College Jamnagar
M B B S
Trending Diseases
Trending Cases
- Login to View the image
X-rays are commonly used in clinical practice to diagnose fractures. Characteristics of the fracture such as the type, deformity & soft tissue / joint involvement are used to guide management. Learn & update your basic radiological approach for “Bone Fractures” & interpretation knowledge & patient care approach with this post.
Radiology Essential5 Likes8 Answers - Login to View the image
F.60yrs. LBA with swelling of legs. 3months.
Dr. Syam Sundar Patro1 Like5 Answers - Login to View the image
Check how quickly can you solve these questions using your clinical knowledge. Solve & get a chance to be the top performer. We are Live Now.
Curofy Quiz0 Like0 Answer - Login to View the image
Check out the answer for Quick Brains quiz.
Curofy Quiz0 Like0 Answer
21 Views
, 1 Like
, 1 Answer