Hemophagocytic syndrome
A classification of rare, non-neoplastic, proliferative disorders of the hematologic system. Primary or familial hemophagocytic lymphohistiocytosis (HLH) is inherited with an autosomal recessive pattern with five known subtypes differentiated by specific genetic mutations. Secondary manifestation of HLH is usually seen in hyperactivated immunologic states such as infection, autoimmune disease or malignancy. Histiocytes in the bone marrow, spleen or lymph nodes become activated to the point that phagocytosis proceeds unchecked. Clinical signs usually present within the first decade and include fever, jaundice, hepatosplenomegaly, lymphadenopathy and skin rash. Prompt initiation of treatment improves survival though prognosis remains poor even with intervention.
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Top doctors who continously share their opinions on Hemophagocytic syndromeEx.central Hospital Dhanbad.1985 ..1993..ex.pathologist .drs Tribedy and Roy Dianostic Lab.kolkata.ex Pathologist.inst of Child Health Kolkata.
Senior Pathologist
School of Tropical Medicine. Kolkata
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The Health City Hospital
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Maharashtra University of Health Sciences Nashik
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BCCL Hospital
Ex. Dy.Cmo
PMCH
MBBS
Parmarth Homeopathic Ausdhalay
M/O Incherge
Homeopathy University Jaipur
DHMS
Tata Central Hospital, Jamadoba
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SCBMC, Cuttack, Orissa
MD(Pathology)
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