Large cell lymphoma

A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, CD30 positive cells. The majority of cases are positive for the anaplastic large cell lymphoma (ALK) protein. The most frequently seen genetic alteration is a t(2;5) translocation. Majority of patients present with advanced disease. The most important prognostic indicator is ALK positivity, which has been associated with a favorable prognosis. (WHO, 2001)

Disease Alternative Name

anaplastic large cell lymphoma
cd30+
ki-1 lymphoma
nhl
cd30 positive anaplastic large cell lymphoma
ki-1+ alcl
nos
ki-1+ anaplastic large cell lymphoma
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