Johnson syndrome

A systemic, serious, and life-threatening disorder characterized by lesions in the skin and mucous membranes that may lead to necrosis. The lesions may appear anywhere in the body but they occur more commonly in the palms, soles, dorsum of the hands, and extensor surfaces. The lesions are vesicular or necrotic in the center, surrounded by an erythematous zone and occupy less than 10% of the body surfaces. The appearance of the mucocutaneous lesions is preceded by an upper respiratory tract infection. It is an immune complex hypersensitivity reaction usually caused by drugs (e.g., sulfa, phenytoin, penicillin), viruses (e.g., herpes simplex, influenza, hepatitis), and malignancies (e.g., carcinoma and lymphoma).

Disease Alternative Name

stevens-johnson syndrome
stevens johnson syndrome
erythema multiforme major
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Concluded Case

Steven Johnson syndrome

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Concluded answer

Severe form of Stevens jhonson syndrome.requires ICU management


Concluded Case

How to differentiate Erythema Multiforme Major (EMM) from Steven- Jonhson Syndrome (SJS) clinically? This  question is r...See More

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More severe cases of Erythema Multiforme Major (EMM) may be confused with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) in its early presentation. However skin lesions of EMM will be predominately Acral. In contrast, th...


Concluded Case

46F She is on MDT for MB(Adult) Leprosy (Other) with grade I disability (ulcer on right sole) and taking Prednisolone fo...See More

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Concluded answer

Yes this is herpes zoster You rightly put her on acyclovir Kindly give the full doses of 800mg 5times a day and tapper off gradually and keep on maintenance dose don't withdraw immidiately Second thing don't stop steroids as she on Rest loc...


Stevens Johnson Syndrome

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